| Autor: |
K F, Swingle, G G, Moore, T J, Grant |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
Archives internationales de pharmacodynamie et de therapie. 221(1) |
| ISSN: |
0003-9780 |
| Popis: |
The anti-inflammatory activity of the sulfonanilide, 4-nitro-2-phenoxymethanesulfonanilide (R-805) has been demonstrated in conventional models (carrageenan-induced edema of the rat's paw, UV-induced erythema of guinea-pig skin, adjuvant-induced arthritis of the rat). R-805 differs from most currently available acidic anti-inflammatory drugs in that its functional acidic group is not carboxyl. The relative anti-inflammatory potency of R-805 is comparable to indomethacin. Calculation of acute therapeutic indices (LD50/ED50) for 8 acidic anti-inflammatory drugs show R-805 to possess a more favourable index than the other drugs examined. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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