| Autor: |
Marcos Fiuza de, Carvalho, Thuliermes Lopes, Pamplona, Márcio Alencar, Barreira, Francisco Vagnaldo Jacuru, Fechine, Lúcio Flávio, Gonzaga-Silva, Ricardo Reges Maia de, Oliveira |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Acta Cirúrgica Brasileira |
| ISSN: |
1678-2674 |
| Popis: |
Purpose To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. Methods Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to evaluate non-voiding contractions (NVC), threshold pressure (TP), baseline pressure (BP), frequency of micturition (FM) and threshold volume (TV). Differences between the groups were analyzed with ANOVA followed by the Tukey test. Results NVC increased in G2 (4.33±2.58) in relation to G1 (1.50±0.55). NVC decreased in G3 (2.00±1.10), G4 (1.50±1.52) and G5 (2.00±1.26) compared to G2 (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
