Translocation (Y;1)(q12;q12) in hematologic malignancies. Report on two new cases, FISH characterization, and review of the literature

Autor:	L, Michaux, I, Wlodarska, E R, Vellosa, G, Verhoef, A, Van Orshoven, J L, Michaux, J M, Scheiff, C, Mecucci, H, Van den Berghe
Rok vydání:	1996
Předmět:	Male Adolescent Chromosomes Human Pair 1 Primary Myelofibrosis Karyotyping Leukemia Myelogenous Chronic BCR-ABL Positive Y Chromosome Humans Trisomy In Situ Hybridization Fluorescence Translocation Genetic Aged
Zdroj:	Cancer genetics and cytogenetics. 86(1)
ISSN:	0165-4608
Popis:	Translocation (Y;1)(q12;q12) is a rare cytogenetic anomaly occurring in hematologic disorders thought to affect stem cells. We report here on two new cases, one end-stage myelofibrosis and one chronic myelomonocytic leukemia. The translocation breakpoints were assessed by conventional cytogenetic techniques in both cases and by FISH in the second case. A partial trisomy of the 1q21-qter region could be demonstrated. The data of the literature are reviewed and the possible pathogenetic mechanisms are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::67a34a039ffa1d73edd3e1d1488e3364 https://pubmed.ncbi.nlm.nih.gov/8616783 Zobrazit plný text záznamu Full Text from ScienceDirect