| Autor: |
Woonghee, Lee, Swarbhanu, Sarkar, Rammyani, Pal, Jung Young, Kim, Hyun, Park, Phuong Tu, Huynh, Abhinav, Bhise, Kondapa Naidu, Bobba, Kwang Il, Kim, Yeong Su, Ha, Nisarg, Soni, Wanook, Kim, Kiwoong, Lee, Jung-Min, Jung, Subramani, Rajkumar, Kyo Chul, Lee, Jeongsoo, Yoo |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ACS applied bio materials. 4(3) |
| ISSN: |
2576-6422 |
| Popis: |
Immuno-positron emission tomography (immuno-PET) is a rapidly growing imaging technique in which antibodies are radiolabeled to monitor their in vivo behavior in real time. However, effecting the controlled conjugation of a chelate-bearing radioactive atom to a bulky antibody without affecting its immunoreactivity at a specific site is always challenging. The in vivo stability of the radiolabeled chelate is also a key issue for successful tumor imaging. To address these points, a facile ultra-stable radiolabeling platform is developed by using the propylene cross-bridged chelator (PCB-TE2A-alkyne), which can be instantly functionalized with various groups via the click reaction, thus enabling specific conjugation with antibodies as per choice. The PCB-TE2A-tetrazine derivative is selected to demonstrate the proposed strategy. The antibody trastuzumab is functionalized with the |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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