| Autor: |
T, Saito, D F, Papolos, D, Chernak, M H, Rapaport, J R, Kelsoe, H M, Lachman |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
American journal of medical genetics. 88(4) |
| ISSN: |
0148-7299 |
| Popis: |
Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein alpha subunit gene Galphaz (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation polymorphism analysis. The frequency of this polymorphism was determined in a control population (n=84) and in patients with BPD (n=88). The data showed a statistical trend toward a difference in the distribution of alleles in patients with BPD compared with control subjects (chi square=3.2, 1 df, P=0.073, two-tailed). No significant difference was detected when the GNAZ polymorphism was analyzed in control subjects and schizophrenia patients (n=63, P=0.92). These data continue to provide some support for a BPD susceptibility gene on 22q11, possibly in linkage disequilibrium with the GNAZ 309 polymorphism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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