| Autor: |
Brittany D, Jenkins, Rachel N, Martini, Rupali, Hire, Andrea, Brown, Briana, Bennett, I'nasia, Brown, Elizabeth W, Howerth, Mary, Egan, Jamie, Hodgson, Clayton, Yates, Rick, Kittles, Dhananjay, Chitale, Haythem, Ali, David, Nathanson, Petros, Nikolinakos, Lisa, Newman, Michele, Monteil, Melissa B, Davis |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 28(4) |
| ISSN: |
1538-7755 |
| Popis: |
Tumor-specific immune response is an important aspect of disease prognosis and ultimately impacts treatment decisions for innovative immunotherapies. The Atypical Chemokine Receptor 1 (ACKR1/DARC) gene, plays a pivotal role in immune regulation and harbors several Single Nucleotide Variants (SNVs) that are specific to Sub-Saharan African Ancestry. In this study, we report the clinical relevance of DARC/ACKR1 tumor expression in breast cancer, in the context of a tumor immune response that may be associated with Sub-Saharan African Ancestry. We found that in infiltrating carcinomas from The Cancer Genome Atlas (TCGA) breast cohort (n=838), African-Americans (AA) have a higher proportion of tumors with low DARC/ACKR1- expression when compared to White Americans (WA), and DARC/ACKR1 tumor expression is positively correlated with pro-inflammatory chemokine, CCL2/MCP-1 (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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