| Autor: |
Bert L H, Beerkens, Çağla, Koç, Rongfang, Liu, Bogdan I, Florea, Sylvia E, Le Dévédec, Laura H, Heitman, Adriaan P, IJzerman, Daan, van der Es |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
ACS chemical biology. 17(11) |
| ISSN: |
1554-8937 |
| Popis: |
G protein-coupled receptors (GPCRs) have been known for decades as attractive drug targets. This has led to the development and approval of many ligands targeting GPCRs. Although ligand binding effects have been studied thoroughly for many GPCRs, there are multiple aspects of GPCR signaling that remain poorly understood. The reasons for this are the difficulties that are encountered upon studying GPCRs, for example, a poor solubility and low expression levels. In this work, we have managed to overcome some of these issues by developing an affinity-based probe for a prototypic GPCR, the adenosine A |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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