Early placenta insulin-like growth factor (pro-EPIL) is overexpressed and secreted by c-erbB-2-positive cells with high invasion potential

Autor:	Burkhard, Brandt, Antje, Roetger, Jean-Michel, Bidart, Jens, Packeisen, Katrin, Schier, Jan-Hendrik, Mikesch, Dirk, Kemming, Werner, Boecker, Dihua, Yu, Horst, Buerger
Rok vydání:	2002
Předmět:	Receptor ErbB-2 Tumor Cells Cultured Gene Expression Humans Intercellular Signaling Peptides and Proteins Breast Neoplasms Neoplasm Invasiveness Pregnancy Proteins Growth Substances Immunohistochemistry
Zdroj:	Cancer research. 62(4)
ISSN:	0008-5472
Popis:	By differential-display PCR a subclone of the SKBR3 cell line with high in vitro transendothelial invasiveness was identified to express increased levels of the INSL-4 gene. This new member of the insulin-like growth factor family encodes for a peptide, designated early placenta insulin-like (EPIL), being expressed in the so-called "invasive" phase of the placental development. Immunohistochemistry on tissue microarrays revealed a heterogeneous expression of EPIL in breast cancer tissue and no expression in the surrounding stroma cells. A coexpression of pro-EPIL and c-erbB-2 could be observed predominantly in cell clusters at the infiltrating edge of the tumor. Our results give new suggestions for the presence of a signaling network of receptor tyrosine kinases underlying breast cancer invasion and metastasis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6754a09d2beec86d0fc984fb631bbe76 https://pubmed.ncbi.nlm.nih.gov/11861376 Zobrazit plný text záznamu