Targeting the Trypanothione Reductase of Tissue-Residing

Autor:	Debarati, Mukherjee, Md, Yousuf, Somaditya, Dey, Sondipon, Chakraborty, Ankur, Chaudhuri, Vinay, Kumar, Biswajyoti, Sarkar, Supriya, Nath, Aabid, Hussain, Aritri, Dutta, Tanushree, Mishra, Biswajit Gopal, Roy, Sushma, Singh, Sibani, Chakraborty, Susanta, Adhikari, Chiranjib, Pal
Rok vydání:	2020
Předmět:	Binding Sites Metallocenes Antiprotozoal Agents Drug Resistance Protozoan Proteins Administration Oral Molecular Docking Simulation Disease Models Animal Mice Structure-Activity Relationship Solubility Drug Design Quinolines Animals Leishmaniasis Visceral NADH NADPH Oxidoreductases Ferrous Compounds Reactive Oxygen Species Mononuclear Phagocyte System Half-Life Leishmania donovani
Zdroj:	Journal of medicinal chemistry. 63(24)
ISSN:	1520-4804
Popis:	Since inception, the magic bullets developed against leishmaniasis traveled a certain path and then dropped down due to either toxicity or the emergence of resistance. The route of administration is also an important concern. We developed a series of water-soluble ferrocenylquinoline derivatives, targeting
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::674582900f9cd63f19d137d182796e52 https://pubmed.ncbi.nlm.nih.gov/33296601 Zobrazit plný text záznamu