[Increasing the concentration of free calcium in thymocytes during gamma-irradiation may induce their death]

Autor: V L, Gabaĭ, A F, Mosin, A M, Poverennyĭ
Rok vydání: 1990
Předmět:
Zdroj: Radiobiologiia. 30(6)
ISSN: 0033-8192
Popis: Free Ca2+ concentration in thymocytes increased 0.5-1.5h after gamma-irradiation (10 Gy) as was measured by Quin-2AM fluorescent probe. Cycloheximide, a protein synthesis inhibitor, suppressed Ca2+ increase and inhibited radiation-induced thymocyte death. EL-4 thymoma cells did not exhibit any changes in free Ca2+ concentration and interphase death after gamma-irradiation. It is believed that the radiation-induced increase of free Ca2+ concentration in thymocytes may induce their death.
Databáze: OpenAIRE