| Autor: |
A A, Potapov, A G, Gavrilov, S A, Goriaĭnov, D A, Gol'bin, P V, Zelenkov, G L, Kobiakov, V A, Okhlopkov, V Iu, Zhukov, L V, Shishkina, V A, Shukhraĭ, V B, Loshchenov, T A, Savel'eva, P V, Grachev, M N, Kholodtsova, S G, Kuz'min, G N, Vorozhtsov |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko. 76(5) |
| ISSN: |
0042-8817 |
| Popis: |
Absence of well-defined borders of the glial tumor due to their infiltrative growth is one of the main issues in neurosurgery. A number of methods for intraoperative visualization are available today. The fluorescent metabolic navigation with 5-aminolevulinic acid (5-ALA) combined with quantitative laser spectroscopy is one of the latest technique. In our series of 99 consecutive patients with brain gliomas (WHO Grade I-IV) we found that visible fluorescence was observed in 68% of cases. Additional use of the laser spectroscopy could increase method sensitivity up to 74% due to accumulation of the protoporphyrine IX in nonfluorescense tumors. It was shown that there are some differences in quantitative fluorescence not only within same tumor (glioblastoma) but also in-between low- and high-grade gliomas. Intraoperative fluorescence and laser spectroscopy are effective and very helpful methods of intraoperative imaging in of intrinsic brain tumor surgery. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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