| Autor: |
Yan, Li, Jamie N, Connarn, Jian, Chen, Zeen, Tong, Maria, Palmisano, Simon, Zhou |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Clinical Pharmacology : Advances and Applications |
| ISSN: |
1179-1438 |
| Popis: |
Background Enasidenib (IDHIFA®, AG-221) is a first-in-class, targeted inhibitor of mutant IDH2 proteins for treatment of relapsed or refractory acute myeloid leukemia. This was a Phase I/II study evaluating safety, efficacy, and pharmacokinetics/pharmacodynamics (PK/PD) of orally administered enasidenib in subjects with advanced hematologic malignancies with an IDH2 mutation. Methods Blood samples for PK and PD assessment were collected. A semi-mechanistic nonlinear mixed effect PK/PD model was successfully developed to characterize enasidenib plasma PK and to assess enasidenib-induced CYP3A activity. Results The PK model showed that enasidenib plasma concentrations were adequately described by a one-compartment model with first-order absorption and elimination; the PD model showed a high capacity to induce CYP3A (Emax=7.36) and a high enasidenib plasma concentration to produce half of maximum CYP3A induction (EC50 =31,400 ng/mL). Monte Carlo simulations based on the final PK/PD model showed that at 100 mg once daily dose there was significant drug accumulation and a maximum of three-fold CYP3A induction after multiple doses. Although the EC50 value for CYP3A induction by enasidenib is high, CYP3A induction was observed due to significant drug accumulation. Conclusion CYP3A induction following enasidenib dosing should be considered when prescribing concomitant medication metabolized via this pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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