[Autoimmune response following administration of a protein preparation from the caudate nuclei of cattle brains to rabbits]

Autor:	V A, Smirnov, V I, Ivanskiĭ, A N, Paniukov
Rok vydání:	1977
Předmět:	Electric Organ Muscular Diseases Muscles Cell Membrane Hypersensitivity Animals Membrane Proteins Cattle Nerve Tissue Proteins Rabbits Caudate Nucleus Autoantibodies
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 84(12)
ISSN:	0365-9615
Popis:	Plasma membranes of bovine caudate nuclei were solubilized by means of Triton X-100. Detergent-extracted membrane proteins were separated by chromatography on DEAE-cellulose and the affinity adsorbent proposed for the isolation of nicotinic cholinergic receptor protein (N-ChR) from Torpedo electrical organ. Half of the rabbits immunized with purified protein preparation developed a syndrome of myasthenia type. This effect resembled the autoimmune response to N-ChR from fish electrical organs. It is assumed that the N-ChR present in the caudate nucleus has antigen determinants similar to N-ChRs of the electrical organs and skeletal muscles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6704ab24d84cb72694f688ab79e57da3 https://pubmed.ncbi.nlm.nih.gov/597605 Zobrazit plný text záznamu