| Autor: |
Daphne H M, Jacobs, Ramona K, Charaghvandi, Nanda, Horeweg, John H, Maduro, Gabrielle, Speijer, Ellen M A, Roeloffzen, Mirjam, Mast, Enja, Bantema-Joppe, Anna L, Petoukhova, Desirée H J G, van den Bongard, Peter, Koper, Anne P G, Crijns, Corrie A M, Marijnen, Helena M, Verkooijen |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Breast Cancer Research and Treatment |
| ISSN: |
1573-7217 |
| Popis: |
Purpose To evaluate and compare health-related quality of life (HRQL) of women with early-stage breast cancer (BC) treated with different radiotherapy (RT) regimens. Methods Data were collected from five prospective cohorts of BC patients treated with breast-conserving surgery and different RT regimens: intraoperative RT (IORT, 1 × 23.3 Gy; n = 267), external beam accelerated partial breast irradiation (EB-APBI, 10 × 3.85 Gy; n = 206), hypofractionated whole breast irradiation(hypo-WBI, 16 × 2.67 Gy; n = 375), hypo-WBI + boost(hypo-WBI-B, 21–26 × 2.67 Gy; n = 189), and simultaneous WBI + boost(WBI-B, 28 × 2.3 Gy; n = 475). Women ≥ 60 years with invasive/in situ carcinoma ≤ 30 mm, cN0 and pN0-1a were included. Validated EORTC QLQ-C30/BR23 questionnaires were used to asses HRQL. Multivariable linear regression models adjusted for confounding (age, comorbidity, pT, locoregional treatment, systemic therapy) were used to compare the impact of the RT regimens on HRQL at 12 and 24 months. Differences in HRQL over time (3–24 months) were evaluated using linear mixed models. Results There were no significant differences in HRQL at 12 months between groups except for breast symptoms which were better after IORT and EB-APBI compared to hypo-WBI at 12 months (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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