| Autor: |
R, Cortés, M, Rivera, L, Martínez Dolz, E, Roselló-Lletí, M J, Sancho-Tello, B, Sevilla, M, Portolés, J, Cosín |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Revista clinica espanola. 209(4) |
| ISSN: |
0014-2565 |
| Popis: |
It was aimed to compare urine B-type natriuretic peptide (BNP) according to left ventricular systolic dysfunction and to investigate its diagnostic value in heart failure (HF) patients.A total of 90 HF outpatients (61 men, age 66 +/- 12) and 30 age- and gender-matched controls were studied.An increase in urine BNP was observed in patients with EF/= 40% compared to EF40% (p0.0001), and controls (p0.0001). Significant correlations between urinary BNP and left ventricular functional parameters were obtained. A multivariate regression analysis was performed and the best model associated with urine BNP included plasma BNP (p0.0001), EF (p = 0.02) and LV volume indexes (p0.0001). The ROC for detection of EF/= 40% using urine BNP levels showed an area under the curve of 0.74 +/- 0.05, (p0.0001). From the ROC curve, the optimal cut-off value (2.30 ng/l) had a 60% sensitivity and 90% specificity. Finally, we performed a binary logistic regression for detection of EF/= 40%, and urine BNP was shown to be a strong predictor with an odds-ratio of 21.Urine BNP levels correlated with left ventricular functional parameters. This biomarker is a useful tool for detecting and diagnosing left ventricular systolic dysfunction in heart failure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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