Sequestration of Proteins in Stress Granules Relies on the In-Cell but Not the

Autor:	Nirnay, Samanta, Sara S, Ribeiro, Mailin, Becker, Emeline, Laborie, Roland, Pollak, Stepan, Timr, Fabio, Sterpone, Simon, Ebbinghaus
Rok vydání:	2021
Předmět:	Superoxide Dismutase-1 Protein Stability Humans Protein Multimerization Phase Transition Stress Granules HeLa Cells Protein Unfolding
Zdroj:	Journal of the American Chemical Society. 143(47)
ISSN:	1520-5126
Popis:	Stress granules (SGs) are among the most studied membraneless organelles that form upon heat stress (HS) to sequester unfolded, misfolded, or aggregated protein, supporting protein quality control (PQC) clearance. The folding states that are primarily associated with SGs, as well as the function of the phase separated environment in adjusting the energy landscapes, remain unknown. Here, we investigate the association of superoxide dismutase 1 (SOD1) proteins with different folding stabilities and aggregation propensities with condensates in cells
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::66ee2b851a833c8776729511c6583868 https://pubmed.ncbi.nlm.nih.gov/34788540 Zobrazit plný text záznamu