[Characteristics of reactogenic and immunogenic properties of the children's variant of the domestic vaccine, 'Gep-A-in-Vak', against hepatitis A]

Autor: V N, Ikoev, M A, Gorbunov, A G, Maĭdaniuk, L G, Karpovich, T V, Kalashnikova, T A, Bektimirov, E V, Karpova, Iu V, Nemtsov, M A, Muntlieva, N I, Kriuk
Rok vydání: 1999
Předmět:
Zdroj: Voprosy virusologii. 44(3)
ISSN: 0507-4088
Popis: Russian cultural concentrated inactivated vaccine protecting from hepatitis A--Hep-A-in-vac was used for immunization of children. The vaccine is slightly reactogenic and completely safe in children aged 3-17 years vaccinated twice in a dose of 0.25 ml. Double immunization of seronegative children with a 1-month interval led to conversion in 89.7% children. In 64.1% children titers of antibodies to hepatitis A virus reached 20 mIU/ml and higher, which indicates rather high antigenic activity of the vaccine.
Databáze: OpenAIRE