| Autor: |
Boubou, Camara, Nassim, Kamar, Jean-Louis, Bonafe, Marie, Danjoux, Bertrand, Suc, Lionel, Rostaing |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 5(2) |
| ISSN: |
1304-0855 |
| Popis: |
We herein describe a case of secondary syphilis hepatitis in a liver transplant patient. This homosexual man presented 15 years after an orthotopic liver transplant with nonsquamous papillomacular rash, mild cytolysis, and anicteric cholestasis. Laboratory tests showed syphilis seroconversionwith a VDRL test titer of 1/256, a Treponema pallidum hemagglutination assay of 1/5120, and a positive immunoglobulin M fluorescent Treponemal antibody absorbance. A liver biopsy performed 13 months after the diagnosis showed low-grade hepatitis with a METAVIR score of A1F1; it also showed moderate, nonspecific portal inflammation consisting primarily of neutrophils, with no evidence of cholestasis. The patient was given benzathine-penicillin (2400000 IU) with a transient increase in prednisolone dosages. Cytolysis rapidly, and cholestasis progressively, disappeared. Results of an immunoglobulin M fluorescent Treponemal antibody absorbance test became negative, whereas the VDRL test and the Treponema pallidum hemagglutination assay titers decreased slightly over time. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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