| Popis: |
A series of 2-[5-chloro-4-methyl-2-(perhydropyrimidin-2-yl iminosulphonyl)phenylthio]alkanoic acids [IV-XI], their methyl esters [XII-XIX], N-(2-dimethylaminoethyl) amides, [XX-XXV] and the corresponding hydrochlorides [XXa-XXIVa] were obtained. The hydrochlorides [XXa, XXIIa, XXIVa] exhibited a comparable or stronger antiarrhythmic activity than the reference drugs, quinidine and procainamide. The influence of the tested compounds on the blood pressure and heart rate of rats as well as the acute toxicity in mice were studied. Some structure-activity relationship were also discussed. |
