Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium

Autor:	N E, Allen, J N, Hobbs, J M, Richardson, R M, Riggin
Rok vydání:	1992
Předmět:	Vancomycin Enterococcus faecium Molecular Sequence Data Drug Resistance Microbial Amino Acid Sequence Peptidoglycan Protein Precursors Uridine Diphosphate N-Acetylmuramic Acid
Zdroj:	FEMS microbiology letters. 77(1-3)
ISSN:	0378-1097
Popis:	In the presence of bacitracin, vancomycin-resistant Enterococcus faecium (vanA phenotype) accumulate UDP-N-acetylmuramyl(UDP-Mur-NAc)-tetrapeptide and a UDP-MurNAc-depsipentapeptide containing lactate substituted for the carboxy-terminal-D-alanine residue. In an in vitro peptidoglycan polymerization assay, the modified precursors function and confer resistance to vancomycin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::66b23a1d974cef35832dcd10978f6254 https://pubmed.ncbi.nlm.nih.gov/1459398 Zobrazit plný text záznamu Plný text