| Autor: |
L F, Chasseaud, T, Taylor, R M, Major, I W, Taylor, V, Luckow, A, Darragh, R F, Lambe |
| Jazyk: |
němčina |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Arzneimittel-Forschung. 33(9) |
| ISSN: |
0004-4172 |
| Popis: |
To study the influence of various in vitro release rates and of coadministration with food on bioavailability of isosorbide dinitrate (ISDN; isoket retard 40) and its mononitrate metabolites from sustained-release formulations the pharmacokinetics of two experimental batches of tablets with different release rates containing 40 mg 14C-ISDN each were studied in six human volunteers. One of the formulations was not only administered after fasting but aslo with a standard meal. In all cases approx. 80% of the administered radioactivity were recovered in the urine and 5% in the faeces during 3 days demonstrating extensive absorption. Any influence of release rates or food on absorption rates could not be detected. When administered after fasting either formulation was bioequivalent. Coadministration of a meal enhanced ISDN plasma levels in some subjects although no statistically significant difference in extent of bioavailability was observed. Availability of the mononitrates was unaffected by food. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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