| Autor: |
Aura, Muntasell, Federico, Rojo, Sonia, Servitja, Carlota, Rubio-Perez, Mariona, Cabo, David, Tamborero, Marcel, Costa-García, María, Martínez-Garcia, Sílvia, Menéndez, Ivonne, Vazquez, Ana, Lluch, Abel, Gonzalez-Perez, Ana, Rovira, Miguel, López-Botet, Joan, Albanell |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(5) |
| ISSN: |
1557-3265 |
| Popis: |
We investigated the value of tumor-infiltrating NK (TI-NK) cells and HLA class I tumor expression as biomarkers of response to neoadjuvant anti-HER2 antibody-based treatment in breast cancer.TI-NK cells and HLA-I were determined by IHC in pretreatment tumor biopsies from two cohorts of patients with HER2-positive breast cancer [discovery cohort (TI-NK cells were significantly associated with pCR in the discovery cohort as well as in the validation cohort (This study identifies baseline TI-NK cells as an independent biomarker with great predictive value for pCR to anti-HER2 antibody-based treatment and points to the complementary value of tumor HLA-I status for defining patient prognosis independently of pCR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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