| Autor: |
A, Fatehullah, Y, Terakado, S, Sagiraju, T L, Tan, T, Sheng, S H, Tan, K, Murakami, Y, Swathi, N, Ang, R, Rajarethinam, T, Ming, P, Tan, B, Lee, N, Barker |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature cell biology. 23(12) |
| ISSN: |
1476-4679 |
| Popis: |
Gastric cancer is among the most prevalent and deadliest of cancers globally. To derive mechanistic insight into the pathways governing this disease, we generated a Claudin18-IRES-CreERT2 allele to selectively drive conditional dysregulation of the Wnt, Receptor Tyrosine Kinase and Trp53 pathways within the gastric epithelium. This resulted in highly reproducible metastatic, chromosomal-instable-type gastric cancer. In parallel, we developed orthotopic cancer organoid transplantation models to evaluate tumour-resident Lgr5 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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