Hyaluronan incorporation into model contact lens hydrogels as a built-in lubricant: Effect of hydrogel composition and proteoglycan 4 as a lubricant in solution

Autor:	Michael, Samsom, Myrto, Korogiannaki, Lakshman N, Subbaraman, Heather, Sheardown, Tannin A, Schmidt
Rok vydání:	2016
Předmět:	Friction Materials Testing Wettability Humans Hydrogels Proteoglycans Hyaluronic Acid Contact Lenses Hydrophilic Lubricants
Zdroj:	Journal of biomedical materials research. Part B, Applied biomaterials. 106(5)
ISSN:	1552-4981
Popis:	Contact lens friction significantly correlates with subjective comfort. Hyaluronan (HA) and proteoglycan 4 (PRG4) are natural boundary lubricants present in the body. The objective of this study was to assess the effect of crosslinked HA into the bulk of model contact lens materials pHEMA, pHEMA/TRIS, and DMAA/TRIS on surface wettability, protein sorption, and boundary lubricating properties at a material-cornea biointerface, both alone and synergistically with PRG4 in solution. Surface wettability was assessed by water contact angle measurement, protein sorption by lysozyme sorption assay, and boundary lubricating properties using an in vitro friction test method. HA incorporation (HA
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::663c955160d4840492b2e81d005a3874 https://pubmed.ncbi.nlm.nih.gov/28914993 Zobrazit plný text záznamu Plný text