| Autor: |
S A, Radema, A, Stronkhorst, H, Bijl, G N, Tytgat, S J, van Deventer |
| Rok vydání: |
2013 |
| Zdroj: |
Inflammatory bowel diseases. 1(3) |
| ISSN: |
1078-0998 |
| Popis: |
Mucosal cells from patients with Crohn's disease regularly express HLA-class II antigens, which are thought to be induced by cytokines, in particular interferon gamma, that are secreted by activated T-cells. Abberant MHC-class II expression by epithelial cells may play a role in diseases characterized by T-cell activation. Activated CD4-positive T-cells are present in the lamina propria of patients with Crohn's disease. In this study we report the results of an open label, single center anti-CD4 ~ trial in patients with steroid refractory Crohn's disease. A rapid and near complete loss of HLA-DR expression by mucosal cells was observed in 10 out of 12 patients, following infusion of the chimeric anti-CD4 antibody M-T412. These results suggest that CD4-positive T-cells are necessary for epithelial class II expression in patients with Crohn's disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
