| Autor: |
Susanna, Croci, Mary Anna, Venneri, Stefania, Mantovani, Chiara, Fallerini, Elisa, Benetti, Nicola, Picchiotti, Federica, Campolo, Francesco, Imperatore, Maria, Palmieri, Sergio, Daga, Chiara, Gabbi, Francesca, Montagnani, Giada, Beligni, Ticiana D J, Farias, Miriam Lucia, Carriero, Laura, Di Sarno, Diana, Alaverdian, Sigrid, Aslaksen, Maria Vittoria, Cubellis, Ottavia, Spiga, Margherita, Baldassarri, Francesca, Fava, Paul J, Norman, Elisa, Frullanti, Andrea M, Isidori, Antonio, Amoroso, Francesca, Mari, Simone, Furini, Mario U, Mondelli, Gen-Covid Multicenter Study, Mario, Chiariello, Alessandra, Renieri, Ilaria, Meloni |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Autophagy. 18(7) |
| ISSN: |
1554-8635 |
| Popis: |
The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNFα production was demonstrated in HEK293 cells transfected with TLR3 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
