| Autor: |
A, Elias, J L, Bono, K, Tilly, P, Rosa |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Wiener klinische Wochenschrift. 110(24) |
| ISSN: |
0043-5325 |
| Popis: |
Borrelia burgdorferi, the causative agent of Lyme disease, grows in vitro in modified Barbour-Stoenner-Kelly (BSK-H) medium. We have studied the effect of increased osmotic strength of culture media on growth of infectious and non-infectious B. burgdorferi strains B31 and N40. Relatively small increases in the NaCl concentration of the medium significantly inhibited growth in infectious as well as non-infectious strains. Growth of low passage, infectious clone B31-4a was more sensitive to increased NaCl concentrations than high passage, non-infectious clone B31-a. Growth of two infectious N40 strains, one low passage (N40-Lp) and one high passage (N40-P31) was more resistant to increased NaCl concentration than growth of infectious B31-4a. Osmotic strength is an important physical parameter for growth of B. burgdorferi in vitro and could influence its ability to adapt and to establish an infection within ticks and mammals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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