| Autor: |
S, Groszkowski, L, Korzycka, A, Szadowska, A, Kamińska, A, Winer |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
Polish journal of pharmacology and pharmacy. 34(5-6) |
| ISSN: |
0301-0244 |
| Popis: |
The condensation of asymmetrically substituted 1,4-bis(haloacyl) piperazines with secondary amines yielded asymmetric 1,4-bis (aminoacyl) piperazines 3-6, which were further transformed into the respective dimethiodides 3b-6b by treatment with methyl iodide. Those compounds were found to inhibit the neuromuscular transmission by blocking the motor end-plate receptors. Compounds containing piperidine moiety and branched acyl chain 4b displayed enhanced activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
