PdCl

Autor:	B, Thirupataiah, Guntipally, Mounika, Gangireddy Sujeevan, Reddy, Jetta Sandeep, Kumar, Kazi Amirul, Hossain, Raghavender, Medishetti, Snigdha, Samarpita, Mahaboobkhan, Rasool, Jayesh, Mudgal, Jessy E, Mathew, Gautham G, Shenoy, C Mallikarjuna, Rao, Kiranam, Chatti, Kishore V L, Parsa, Manojit, Pal
Rok vydání:	2021
Předmět:	Male Sulfonamides Embryo Nonmammalian Knee Joint Molecular Structure Anti-Inflammatory Agents Arthritis Experimental Catalysis Cyclic Nucleotide Phosphodiesterases Type 4 Molecular Docking Simulation Mice Structure-Activity Relationship RAW 264.7 Cells Isocoumarins Animals Female Phosphodiesterase 4 Inhibitors Rats Wistar Palladium Zebrafish Protein Binding
Zdroj:	European journal of medicinal chemistry. 221
ISSN:	1768-3254
Popis:	While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfonyl/aminocarboxamide moiety to the C-3 benzene ring attached to the isocoumarin framework. This new class of isocoumarins were synthesized via a PdCl
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::65e763f432a55d48daf040d57ef951bd https://pubmed.ncbi.nlm.nih.gov/33992926 Zobrazit plný text záznamu Full Text from ScienceDirect