Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA

Autor:	Zhongxing, Liang, Peijian, He, Yiran, Han, C Chris, Yun
Rok vydání:	2021
Předmět:	Intestines Mice Stem Cells Animals Lysophospholipids Signal Transduction
Zdroj:	Cellular and molecular gastroenterology and hepatology. 14(1)
ISSN:	2352-345X
Popis:	Regeneration of the epithelium by stem cells in the intestine is supported by intrinsic and extrinsic factors. Lysophosphatidic acid (LPA), a bioactive lipid mediator, regulates many cellular functions, including cell proliferation, survival, and cytokine secretion. Here, we identify LPAWe have used genetic mouse models of conditional deletion of Lpar5, Lpar5Conditional loss of Lpar5 induced ablation of the intestinal mucosa, which increased morbidity of Lpar5LPA
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::65aa8a0edc50e558755ab4dba4818678 https://pubmed.ncbi.nlm.nih.gov/35390517 Zobrazit plný text záznamu