Aortic stiffness is associated with left ventricular diastolic dysfunction in systemic lupus erythematosus: a controlled transesophageal echocardiographic study
| Autor: | Carlos A, Roldan, Ihab B, Alomari, Khaled, Awad, Nathan M, Boyer, Clifford R, Qualls, Ernest R, Greene, Wilmer L, Sibbitt |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Hemodynamics Reproducibility of Results Aorta Thoracic Middle Aged Ventricular Function Left Article Ventricular Dysfunction Left Cross-Sectional Studies Vascular Stiffness Diastole Predictive Value of Tests Case-Control Studies Elastic Modulus Humans Lupus Erythematosus Systemic Female Echocardiography Transesophageal |
| Zdroj: | Clinical cardiology. 37(2) |
| ISSN: | 1932-8737 |
| Popis: | Aortic stiffness and left ventricular (LV) diastolic dysfunction are common and associated with increased morbidity and mortality in systemic lupus erythematosus (SLE).In SLE, aortic stiffness and LV diastolic dysfunction may be associated.This 6-year-duration, cross-sectional, and controlled study was conducted in 76 SLE patients (69 women; mean age, 37 ± 12 years) and 26 age- and sex-matched healthy controls. All subjects underwent clinical and laboratory evaluations and transesophageal echocardiography (TEE) to assess LV diastolic function and stiffness of the descending thoracic aorta using the pressure-strain elastic modulus (PSEM). To validate results using PSEM, aortic strain, stiffness, and distensibility were assessed.Patients as compared with controls had higher PSEM (8.14 ± 4.25 vs 5.97 ± 2.31 U, P0.001) and had lower mitral inflow E/A and septal and lateral mitral annulus tissue Doppler E'/A' velocity ratios, longer isovolumic relaxation time, lower septal and lateral mitral annulus E' velocities, and higher mitral E/septal E' and mitral E/lateral E' velocity ratios (all P ≤ 0.03), all indicative of LV diastolic dysfunction. In patients, PSEM was correlated with parameters of LV diastolic dysfunction (all P0.05), was independently negatively associated with E/A and E'/A' ratios and E' velocities, and was positively associated with E/E' ratios (P ≤ 0.02 for each parameter and P0.001 for all parameters as a profile). Aortic strain, stiffness, and distensibility were also worse in patients than in controls (all P0.05) and were correlated with parameters of LV diastolic dysfunction (all P ≤ 0.03).Aortic stiffness is independently associated with LV diastolic dysfunction in young adult patients with SLE. |
| Databáze: | OpenAIRE |
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