Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood

Autor:	J S, Lobel, R T, O'Brien, S, McIntosh, G T, Aspnes, R L, Capizzi
Rok vydání:	1979
Předmět:	Male Adolescent Remission Spontaneous Drug Synergism Drug Administration Schedule Leukemia Lymphoid Drug Hypersensitivity Methotrexate Bone Marrow Child Preschool Meningeal Neoplasms Asparaginase Humans Drug Therapy Combination Female Neoplasm Metastasis Child
Zdroj:	Cancer. 43(3)
ISSN:	0008-543X
Popis:	Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3 partial remissions, and 5 failures. Responsiveness to Asn'ase seemed necessary for successful induction with the drug combinations. Maintenance therapy in 18 children produced a median hematologic remission of 31 weeks (range 3-85 weeks). During remission, 2 children developed central nervous system leukemia and 2 died of infection. The mean maximally tolerated dose of MTX was 361 mg/m2. The results of this trial suggest therapeutic synergy in maintenance therapy and the capability of Asn'ase to attenuate MTX toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6583a41d14865059436f7c030c6dba99 https://pubmed.ncbi.nlm.nih.gov/284840 Zobrazit plný text záznamu Plný text