| Autor: |
Andrea, Casadei-Gardini, Giorgia, Marisi, Vincenzo, Dadduzio, Laura, Gramantieri, Luca, Faloppi, Paola, Ulivi, Francesco Giuseppe, Foschi, Emiliano, Tamburini, Caterina, Vivaldi, Mario Domenico, Rizzato, Luca, Ielasi, Matteo, Canale, Fabio, Conti, Britt, Rudnas, Lorenzo, Fornaro, Nicola, Silvestris, Marianna, Silletta, Giovanni Gerardo, Cardellino, Sara, Lonardi, Francesca, Fornari, Giulia, Orsi, Giulia, Rovesti, Vittorina, Zagonel, Stefano, Cascinu, Mario, Scartozzi |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(17) |
| ISSN: |
1557-3265 |
| Popis: |
After 10 years of clinical practice and research studies, there are still no validated prognostic or predictive factors of response to sorafenib for hepatocellular carcinoma (HCC). On the basis of the results of our two retrospective studies, we designed the multicenter INNOVATE study with the aim to validate the role of nitric oxide synthaseThis prospective multicenter study was conducted at 10 centers in Italy. All eligible patients received a continuous oral treatment with 400 mg of sorafenib twice daily. Genotyping analysis was performed forA total of 165 patients were enrolled between March 2016 and June 2018.The INNOVATE study met the primary endpoint, confirming that patients with advanced HCC with |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
