| Autor: |
Rui-Hua, Mi, Lin, Chen, Ya-Lan, Zhou, Dong-Bei, Li, Sha, Liu, Xiao-Jiao, Wang, Jia, Liu, Min-Fang, Wang, Xiao-Miao, Ma, Zhi-Chun, Li, Hong-Mian, Zhao, Yu-Lin, Xu, Shu-Xia, Chen, Hai-Ping, Yang, Zhi-Qiang, Guo, Chun-Lai, Luan, Shu-Li, Guo, Qing-Lin, Song, Xu-Dong, Wei |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 29(1) |
| ISSN: |
1009-2137 |
| Popis: |
To explore the synergistic immunomodulatory mechanism of interferon alpha-1b, interleukin-2 and thalidomide (ITI) regimen on patients with acute myeloid leukemia (AML).Sixty eight untreated de novo or relapsed or refractory or maintenance therapy patients with AML admitted in the Affiliated Cancer Hospital of Zhengzhou University and the other 11 medical units from March 2016 to May 2019 were treated with ITI regimen. Peripheral blood specimen per patient was collected into EDTA-K3 anticoagulation vacuum tube before the administration of ITI and 3 months after the treatment; peripheral blood lymphocyte subsets and perforin and Granzyme B expression were analyzed by using flow cytometry; the levels of VEGF, IFN-γ, TNF-α and IL-6 in the plasma were detected by using a cytometric bead array. Thirty-five healthy subjects from the hospital physical examination centre were selected as normal controls.The ratio of CD4The ITI regimen can raise the ratio of CD4干扰素α-1b、白介素-2联合沙利度胺方案治疗急性髓系白血病免疫调节作用的协同机制研究.探讨干扰素α-1b、白介素-2联合沙利度胺（简称"干白沙"方案）治疗急性髓系白血病（AML）的免疫调节的协同作用机制。.对2016年3月至2019年5月郑州大学附属肿瘤医院等11家医疗单位收治的初治或复发/难治性或行维持治疗的且自愿接受"干白沙"方案治疗的68例AML患者，采集患者用药前1天及规范用药3个月后的晨起空腹外周血标本，采用流式细胞术检测外周血淋巴细胞亚群及NK细胞颗粒酶B及穿孔素表达水平；微量样本多重定量技术（CBA）检测血浆中VEGF、IFN-γ、TNF-α、IL-6等4种细胞因子的表达水平。对照组为35例本院体检中心的健康体检者。.治疗前患者外周血CD4"干白沙"方案可提高外周血CD4 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
