| Autor: |
Colleen, Bailey, David J, Collins, Nina, Tunariu, Matthew R, Orton, Veronica A, Morgan, Thorsten, Feiweier, David J, Hawkes, Martin O, Leach, Daniel C, Alexander, Eleftheria, Panagiotaki |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Frontiers in Oncology |
| ISSN: |
2234-943X |
| Popis: |
Purpose To examine the usefulness of rich diffusion protocols with high b-values and varying diffusion time for probing microstructure in bone metastases. Analysis techniques including biophysical and mathematical models were compared with the clinical apparent diffusion coefficient (ADC). Methods Four patients were scanned using 13 b-values up to 3,000 s/mm2 and diffusion times ranging 18–52 ms. Data were fitted to mono-exponential ADC, intravoxel incoherent motion (IVIM), Kurtosis and Vascular, extracellular, and restricted diffusion for cytometry in tumors (VERDICT) models. Parameters from the models were compared using correlation plots. Results ADC and IVIM did not fit the data well, failing to capture the signal at high b-values. The Kurtosis model best explained the data in many voxels, but in voxels exhibiting a more time-dependent signal, the VERDICT model explained the data best. The ADC correlated significantly (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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