Polymorphisms of Selected DNA Repair Genes and Lung Cancer in Chromium Exposure
| Autor: | E, Halasova, T, Matakova, M, Skerenova, M, Krutakova, P, Slovakova, A, Dzian, S, Javorkova, M, Pec, K, Kypusova, J, Hamzik |
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| Rok vydání: | 2016 |
| Předmět: |
Aged
80 and over Chromium Male Lung Neoplasms Polymorphism Genetic DNA Repair Genotype Middle Aged Prognosis DNA-Binding Proteins Survival Rate MutS Homolog 2 Protein Risk Factors Case-Control Studies Occupational Exposure Humans Female Genetic Predisposition to Disease MutL Protein Homolog 1 Aged Follow-Up Studies Neoplasm Staging |
| Zdroj: | Advances in experimental medicine and biology. 911 |
| ISSN: | 0065-2598 |
| Popis: | Chromium is a well-known mutagen and carcinogen involved in lung cancer development. DNA repair genes play an important role in the elimination of genetic changes caused by chromium exposure. In the present study, we investigated the polymorphisms of the following DNA repair genes: XRCC3, participating in the homologous recombination repair, and hMLH1 and hMSH2, functioning in the mismatch repair. We focused on the risk the polymorphisms present in the development of lung cancer regarding the exposure to chromium. We analyzed 106 individuals; 45 patients exposed to chromium with diagnosed lung cancer and 61 healthy controls. Genotypes were determined by a PCR-RFLP method. We unravelled a potential for increased risk of lung cancer development in the hMLH1 (rs1800734) AA genotype in the recessive model. In conclusion, gene polymorphisms in the DNA repair genes underscores the risk of lung cancer development in chromium exposed individuals. |
| Databáze: | OpenAIRE |
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