| Autor: |
M I, Ibragimova, V N, Chushnikov, V N, Moiseev, V Iu, Petukhov, E P, Zheglov, G V, Cherepnev |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Biofizika. 58(2) |
| ISSN: |
0006-3029 |
| Popis: |
Changes in Fe(3+)-transferrin (Fe(3+)-Tf) and Cu(2+)-ceruloplasmin (Cu(2+)-Cp) concentrations in venous blood sampled from anemic patients with urinary bladder and kidney cancer in I-IV stages were investigated using electron paramagnetic resonance spectroscopy. It was established that at malignancy-associated anemia the paramagnetic Fe3+ ion concentration in transferrin is below a norm, while in anemic non-oncology patients the Tf iron saturation is normal. Moreover, in patients with malignancy-associated anemia the Cu(2+)-Cp average value is nearly twice as large as that for healthy volunteers (confidence probability P). It was shown that simultaneous EPR measuring of paramagnetic centers (such as Fe(3+)-Tf and Cu(2+)-Cp) in blood of anemic patients can be used as a biomarker for urological cancer diagnosis even at early stages of the growth of a malignant tumor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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