Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development

Autor:	G, Eberl, H J, Fehling, H, von Boehmer, H R, MacDonald
Rok vydání:	1999
Předmět:	Killer Cells Natural Mice Inbred C57BL Mice Knockout Mice Receptors Antigen T-Cell alpha-beta T-Lymphocytes Animals Cell Differentiation Female Receptors Antigen T-Cell gamma-delta Hematopoietic Stem Cells
Zdroj:	European journal of immunology. 29(6)
ISSN:	0014-2980
Popis:	Most natural killer T (NKT) cells express a highly skewed alphabeta TCR repertoire, consisting of an invariant V alpha14-J alpha281 chain paired preferentially with a polyclonal Vbeta8.2 chain. This repertoire is positively selected by the monomorphic CD1d molecule expressed on cells of hematopoietic origin. The origin of NKT cells and their lineage relationship to conventional T cells is controversial. We show here that the development of NKT cells is absolutely dependent on expression of the pre-TCRalpha chain, in marked contrast to conventional T cells which arise in significant numbers even in the absence of a functional pre-TCR. Distinct developmental requirements for pre-TCR expression in the NKT and T cell lineages may reflect differences in the ability of the TCRalphabeta to substitute functionally for the pre-TCR in immature precursor cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::64e45c680f04b38dd33f3db103411bf6 https://pubmed.ncbi.nlm.nih.gov/10382759 Zobrazit plný text záznamu Plný text