| Autor: |
M J, Dominguez, M, Vacas, Y, Sáez, I, Olabarría, A, Velasco, J A, Iriarte, J, Forn |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Clinical therapeutics. 7(3) |
| ISSN: |
0149-2918 |
| Popis: |
The biological effects of a new antiplatelet agent, triflusal, were evaluated in patients with cardiac valvular prostheses. Each patient received 900 mg/day of oral triflusal for 30 days. Triflusal significantly inhibited platelet aggregation induced by adenosine diphosphate (1 to 5 mumol) or epinephrine (12.5 mumol), showing a slight effect on bleeding time (basal: 6 +/- 1.7 min; 30 days of treatment: 8.0 +/- 2.7 min). Serum levels of thromboxane B2 were significantly reduced during treatment, but changes in serum levels of 6-keto-prostaglandin F1 alpha were not observed, suggesting that triflusal does not affect prostacyclin biosynthesis by the vascular wall. The results show that triflusal has a marked inhibitory and selective effect on platelet function in patients with cardiac valvular prostheses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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