| Autor: |
R H, Hilderman, M, Martin, J K, Zimmerman, E B, Pivorun |
| Rok vydání: |
1991 |
| Předmět: |
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| Zdroj: |
The Journal of biological chemistry. 266(11) |
| ISSN: |
0021-9258 |
| Popis: |
Adenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) has been implicated as a modulator of cell stress. We have performed binding studies which indicate that membranes from all tissues tested bind tritium-labeled Ap4A. The characteristics of Ap4A binding were determined on brain membrane homogenates after development of an optimized in vitro filter-binding assay. Ap4A binding is specific for adenylated dinucleotides and for the length of the phosphate bridge. A Kd of 0.71 microM for Ap4A was determined. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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