Toxicity and genotoxicity of antimalarial alkaloid rich extracts derived from Mitragyna inermis O. Kuntze and Nauclea latifolia

Autor:	F, Traore, M, Gasquet, M, Laget, H, Guiraud, C, Di Giorgio, N, Azas, O, Doumbo, P, Timon-David
Rok vydání:	2000
Předmět:	Salmonella typhimurium Plants Medicinal Mutagenicity Tests Plant Extracts Carbocyanines Flow Cytometry Kidney Mali Monocytes Membrane Potentials Antimalarials Kinetics Mice Alkaloids Liver Microscopy Fluorescence Animals Humans Comet Assay Lymphocytes Medicine African Traditional DNA Damage
Zdroj:	Phytotherapy research : PTR. 14(8)
ISSN:	0951-418X
Popis:	The toxicity and the genotoxicity of antimalarial alkaloid rich extracts derived from two plants used in traditional medicine in Mali (Mitragyna inermis (Willd.) O. Kuntze Rubiaceae and Nauclea latifolia (Sm.) Rubiaceae) were evaluated on in vitro and in vivo systems. The results demonstrated that an alkaloid rich extract derived from M. inermis induced a strong inhibition of protein synthesis in mammalian cells but did not exhibit mutagenic or genotoxic activity. An alkaloid rich extract derived from N. latifolia could interact in vitro with DNA of bacteria and mammalian cells, leading to G2-M cell cycle arrest and heritable DNA-damage, as well as inducing in vivo single-strand breaks in liver, kidney and blood cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::64c43952ffd9fcc87334629d3a4d01ca https://pubmed.ncbi.nlm.nih.gov/11113997 Zobrazit plný text záznamu Plný text