Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21

Autor:	Junhua, Miao, Mutao, Xu, Yuhuan, Kuang, Shuhong, Pan, Jianyuan, Hou, Pengxiu, Cao, Xianglin, Duan, Yanzhong, Chang, Habelhah, Hasem, Nan, Zhou, Ke, Tan, Yumei, Fan
Rok vydání:	2020
Předmět:	Cyclin-Dependent Kinase Inhibitor p21 Caspase 3 Ubiquitin Iron JNK Mitogen-Activated Protein Kinases Ubiquitination Apoptosis Hydrogen Peroxide Mitochondria Up-Regulation Deferasirox Oxidative Stress HEK293 Cells Cytoprotection Proteolysis Humans Signal Transduction
Zdroj:	Biochemical and biophysical research communications. 524(3)
ISSN:	1090-2104
Popis:	Deferasirox (DFX) is an iron chelator approved for the treatment of iron overload diseases. However, the role of DFX in oxidative stress-induced cell apoptosis and the exact molecular mechanisms underlying these processes remain poorly understood and require further investigation. In this study, we found that DFX rendered resistant to H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::64b307af43f7d290d049d7db3a7c04c5 https://pubmed.ncbi.nlm.nih.gov/32035614 Zobrazit plný text záznamu Full Text from ScienceDirect