| Autor: |
Jennifer L, Reid, Thomas C, Wright, Mark H, Stoler, Jack, Cuzick, Philip E, Castle, Janel, Dockter, Damon, Getman, Cristina, Giachetti |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
American journal of clinical pathology. 144(3) |
| ISSN: |
1943-7722 |
| Popis: |
This study determined the longitudinal clinical performance of a high-risk human papillomavirus (HR-HPV) E6/E7 RNA assay (Aptima HPV [AHPV]; Hologic, San Diego, CA) compared with an HR-HPV DNA assay (Hybrid Capture 2 [HC2]; Qiagen, Gaithersburg, MD) as an adjunctive method for cervical cancer screening.Women 30 years or older with a negative result for intraepithelial lesions or malignancy cytology (n = 10,860) positive by AHPV and/or HC2 assays and randomly selected women negative by both assays were referred to colposcopy at baseline. Women without baseline cervical intraepithelial neoplasia (CIN) grade 2 or higher (CIN2+) continued into the 3-year follow-up.The specificity of AHPV for CIN2 or lower was significantly greater at 96.3% compared with HC2 specificity of 94.8% (P.001). Estimated sensitivities and risks for detection of CIN2+ were similar between the two assays. After 3 years of follow-up, women negative by either human papillomavirus test had a very low risk of CIN2+ (0.3%) compared with CIN2+ risk in women with positive AHPV results (6.3%) or positive HC2 results (5.1%).These results support the use of AHPV as a safe and effective adjunctive cervical cancer screening method. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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