Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse
| Autor: | Yuko, Yamakage, Hitomi, Tsuiji, Takao, Kohno, Himari, Ogino, Takashi, Saito, Takaomi C, Saido, Mitsuharu, Hattori |
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| Rok vydání: | 2019 |
| Předmět: |
Mice
Knockout Extracellular Matrix Proteins Amyloid beta-Peptides Cell Adhesion Molecules Neuronal Serine Endopeptidases Mice Transgenic Nerve Tissue Proteins Amyloid beta-Protein Precursor Disease Models Animal Mice Reelin Protein ADAMTS Proteins Gene Expression Regulation Alzheimer Disease Animals Humans |
| Zdroj: | Biologicalpharmaceutical bulletin. 42(3) |
| ISSN: | 1347-5215 |
| Popis: | Reelin is a secreted protein that antagonizes the deposition and toxicity of amyloid β peptide (Aβ). Therefore, augmentation of Reelin activity may ameliorate Alzheimer's disease (AD). We have recently reported that a disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS-3) cleaves and inactivates Reelin in the mouse brain. In the present study, we investigated the effect of reducing ADAMTS-3 on deposition of Aβ by crossbreeding drug-inducible ADAMTS-3 conditional knock-out (cKO) mice with "next-generation" AD model mice. We found that reducing ADAMTS-3 inhibited deposition of Aβ significantly in App |
| Databáze: | OpenAIRE |
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