Phase II pilot study of combined chemohormonal therapy with doxorubicin and estramustine in metastatic prostate cancer

Autor: N B, Haas, J, Manola, G, Hudes, D L, Citrin, M S, Kies, T E, Davis
Rok vydání: 2001
Předmět:
Zdroj: American journal of clinical oncology. 23(6)
ISSN: 0277-3732
Popis: Twenty-nine patients with progressive hormone-refractory metastatic adenocarcinoma of the prostate were treated with daily estramustine phosphate at 10 mg/kg, and I.V. doxorubicin 50 mg/m2 every 3 weeks. Twenty-six patients were evaluable. Four of seven patients with nonosseous measurable disease had partial responses lasting 3 to 10 months. Eleven of 19 patients with osseous metastases had stable disease or improvement on bone scan, 6 of these for 7 months or longer. Median time to progression was 20 weeks, and the median survival was 43 weeks.
Databáze: OpenAIRE