In vitro generation of secondary cell-mediated cytotoxic response against a syngeneic Gross virus-induced lymphoma in rats
| Autor: | M, Glaser, G D, Bonnard, R B, Herberman |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Immunity Cellular Mice Inbred BALB C Time Factors Dose-Response Relationship Drug Lymphoma Lymphoid Tissue Mice Inbred A T-Lymphocytes In Vitro Techniques Cytotoxicity Tests Immunologic Rats Mice Inbred C57BL Mice Species Specificity Mice Inbred DBA AKR murine leukemia virus Animals Immunologic Memory Spleen Antilymphocyte Serum |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 116(2) |
| ISSN: | 0022-1767 |
| Popis: | Cell-mediated cytotoxic responses against a syngeneic Gross virus-induced lymphoma, (C58NT)D, in W/Fu rats were generated in vitro by using mixed lymphocyte-tumor cell cultures. The source of responding cells was either spleens from normal rats or spleens from rats carrying or having rejected (C58NT)D tumors. Mitomycin C-treated (C58NT)D tumor cells were used as stimulating cells. The secondary anti-tumor cytotoxic response occurred more rapidly and reached higher levels than the primary response, and it was antigen specific. T cells, but nor B cells or macrophages, were essential for both the induction and the effector phases of the secondary anti-tumor responses. These data suggest that specific memory T cells persist for long periods of time in the lymphoid organs of (C58NT)D immune rats, which can rapidly become cytotoxic upon re-exposure to antigen. |
| Databáze: | OpenAIRE |
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