| Autor: |
O M, Abdelatif, F W, Chandler, C G, Pantazis, B S, McGuire |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Archives of pathologylaboratory medicine. 114(12) |
| ISSN: |
0003-9985 |
| Popis: |
Tissues from two patients with disseminated histiocytosis X (Letterer-Siwe disease) in which histiocytosis X cells exhibited histologic and cytologic features of malignancy were evaluated by in situ hybridization with the use of biotinylated nucleic acid probes to c-myc and H-ras oncogenes. Enhanced expression of these oncogenes was observed in mononucleated and multinucleated cells of histiocytosis X in the terminal proliferative phase but not in the early quiescent phase of Letterer-Siwe disease in both patients. Our findings indicate that deregulation of c-myc and H-ras in histiocytosis X are late events that likely confer a selective growth advantage to histiocytosis X cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
