Identification and molecular modeling of new quinolin-2-one thiosemicarbazide scaffold with antimicrobial urease inhibitory activity

Autor:	Mohammed A I, Elbastawesy, Yaseen A M M, El-Shaier, Mohamed, Ramadan, Alan B, Brown, Ashraf A, Aly, Gamal El-Din A, Abuo-Rahma
Rok vydání:	2019
Předmět:	Molecular Docking Simulation Structure-Activity Relationship Anti-Infective Agents Bacteria Catalytic Domain Fungi Enzyme Inhibitors Quinolones Urease Semicarbazides
Zdroj:	Molecular diversity. 25(1)
ISSN:	1573-501X
Popis:	A new series of 6-substituted quinolin-2-one thiosemicarbazides 6a-j has been synthesized. The structure of the target compounds was proved by different spectroscopic and elemental analyses. All the designed final compounds were evaluated for their in vitro activity against the urease-producing R. mucilaginosa and Proteus mirabilis bacteria as fungal and bacterial pathogens, respectively. Moreover, all compounds were in vitro tested as potential urease inhibitors using the cup-plate diffusion method. Compounds 6a and 6b were the most active with (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::64414272457c456692f75632bf761b0c https://pubmed.ncbi.nlm.nih.gov/31916112 Zobrazit plný text záznamu Full text from SpringerLink