Post-Procedural Bivalirudin Infusion Following Primary PCI to Reduce Stent Thrombosis

Autor:	Tim, Kinnaird, Khaled, Yazji, Laurence, Thornhill, Mehmood, Butt, Nicholas, Ossei-Gerning, Anirban, Choudhury, Rito, Mitra, Richard, Anderson
Rok vydání:	2016
Předmět:	Aged 80 and over Male Heparin Thrombosis Hirudins Middle Aged Antithrombins Peptide Fragments Recombinant Proteins Survival Rate Percutaneous Coronary Intervention Humans Female Stents Aged
Zdroj:	Journal of interventional cardiology. 29(2)
ISSN:	1540-8183
Popis:	Prolonging infusions may abrogate the acute stent thrombosis (ST) associated with bivalirudin use during primary PCI but at an increased cost. We hypothesized that continuing the bivalirudin infusion commenced during the procedure at the PCI recommended dose until infusion end would prevent excess early ST.Baseline demographics, procedural data and outcomes were gathered prospectively on 1395 consecutive patients undergoing primary PCI. The choice of bivalirudin versus heparin was at the cardiologist's discretion. Local protocol recommended continuation of the procedural bivalirudin at the PCI dose until infusion end.Patients' mean age was 62.8 ± 13.1years with 11.4% presenting with shock. The majority of patients underwent PCI using bivalirudin with fewer using heparin (87.7 vs. 12.3%, P 0.0001). Glycoprotein inhibitor bailout rates were 6.1% with bivalirudin and 36.3% with heparin (P 0.0001). Calculated on an individual patient basis the median intra-procedure duration of the bivalirudin infusion was 30(IQR 21-43) minutes and post-procedure 49(32-66) minutes. The acute (24-hours) ST rates were 4/1224 with bivalirudin ± GPI (0.3%) and 0/171 with heparin ± GPI (0%, P = 0.41). The sub-acute (24-hours to 30-days) ST rates were 3/1224 for bivalirudin ± GPI (0.3%) and 2/171 with heparin ± GPI (1.2%, P = 0.11). In total the early (30-days) ST rates were 7/1224 for bivalirudin ± GPI (0.6%) and 2/171 with heparin ± GPI (1.2%, P = 0.31). Acute ST was significantly more likely to occur in clopidogrel-loaded patients than prasugrel/ticagrelor patients (2.7 vs. 0.5%, P = 0.003).Continuing the bivalirudin infusion commenced during the procedure at the PCI recommended dose until infusion end combined with potent P2 Y12 inhibitors ameliorates excess early stent thrombosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6424f8de55ee841000acd3bfe28f1f15 https://pubmed.ncbi.nlm.nih.gov/26822753 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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