| Autor: |
Yukari, Kobayashi, Naga Lakshmi, Sudini, June-Wha, Rhee, Marie, Aymami, Kegan J, Moneghetti, Sara, Bouajila, Yuhei, Kobayashi, Juyong B, Kim, Ingela, Schnittger, Jeffery J, Teuteberg, Kiran K, Khush, William F, Fearon, Francois, Haddad |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
JACC. Heart failure. 5(12) |
| ISSN: |
2213-1787 |
| Popis: |
This study investigated to define graft dysfunction and to determine its incremental association with long-term outcome after heart transplantation (HT).Although graft failure is an established cause of late mortality after HT, few studies have analyzed the prognostic value of graft dysfunction at 1- and 5-year follow-up of HT.Patients who underwent HT and completed their first annual evaluation with right heart catheterization and echocardiography at Stanford University between January 1999 and December 2011 were included in the study. Hierarchical clustering was used to identify modules to capture independent features of graft dysfunction at 1 year. The primary endpoint for analysis consisted of the composite of cardiovascular mortality, re-transplantation, or heart failure hospitalization within 5 years of HT. The study further explored whether changes in graft dysfunction between 1 and 5 years were associated with 10-year all-cause mortality.A total of 215 HT recipients were included in the study. Using hierarchical clustering, 3 functional modules were identified; among them, left ventricular global longitudinal strain (LVGLS), stroke volume index, and right atrial pressure (RAP) or pulmonary capillary wedge pressure (PCWP) captured key features of graft function. Graft dysfunction based on pre defined LVGLS in absolute value14%, stroke volume index 35 ml/mRAP and LVGLS at the first annual evaluation provide complementary prognostic information in predicting 5-year outcome after HT. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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